See the full list. A man awakens from a coma, only to discover that someone has taken on his identity and that no one, not even his wife , believes him. With the help of a young woman, he sets out to prove who he is.
Movies / TV
Atxn7, a subunit of SAGA chromatin remodeling complex, is subject to polyglutamine expansion at the amino terminus, causing spinocerebellar ataxia type 7 SCA7 , a progressive retinal and neurodegenerative disease. To understand the scope of Atxn7-dependent regulation of Non-stop, substrates of the deubiquitinase were sought. Mutation of Atxn7 and non-stop leads to aberrant gene expression, defective non-homologous end joining, decreased immune response, reduced replicative lifespan, neurodegeneration, blindness, tumorigenesis, and cancer Glinsky et al. SCA7 disease is characterized by progressive cone-rod dystrophy leading to blindness, and progressive degeneration of the spine and cerebellum Martin, ; Garden, In Drosophila , loss of Atxn7 leads to a phenotype similar to overexpression of the polyQ-expanded amino terminal truncation of human Atxn7 Latouche et al. Once released, the module acts as a gain-of-function, leading to reduced ubiquitination of H2B. Similarly, the mammalian DUBm binds and deubiquitinates substrates without Atxn7 in vitro , albeit at a lower rate Lan et al. Consistent with Non-stop release and over activity mediating the Drosophila Atxn7 loss-of-function phenotype, reducing non-stop copy number alleviates lethality associated with loss of Atxn7 Mohan et al. Non-stop is a critical mediator of retinal axon guidance and important for glial cell survival Weake et al.
If I wanted to read my way through a film that features words dancing around the screen as if they were waltzing Post-Its, I would have sat through a foreign movie with subtitles instead. But what would modern-day thrillers be these days without cell phones as a shorthand way to advance the plot and reduce the need for any actual clever repartee between characters? Especially when the clock is ticking down the minutes until something either goes boo or boom. Certainly, this mile-high action flick would barely get off the ground without such technological aids, considering its premise is as reliant on Miss Marple mysteries—specifically, the gathering of potential perpetrators who conform to certain types—as it is on digital devices. As most frequent flyers, know there are rules about phone use once you leave the gate.